Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment
نویسندگان
چکیده
منابع مشابه
Monocyte chemoattractant protein 1 mediates retinal detachment-induced photoreceptor apoptosis.
Photoreceptor apoptosis is a major cause of visual loss in retinal detachment (RD) and several other visual disorders, but the underlying mechanisms remain elusive. Recently, increased expression of monocyte chemoattractant protein 1 (MCP-1) was reported in vitreous humor samples of patients with RD and diabetic retinopathy as well as in the brain tissues of patients with neurodegenerative dise...
متن کاملPhotoreceptor cell death and rescue in retinal detachment and degenerations.
Photoreceptor cell death is the ultimate cause of vision loss in various retinal disorders, including retinal detachment (RD). Photoreceptor cell death has been thought to occur mainly through apoptosis, which is the most characterized form of programmed cell death. The caspase family of cysteine proteases plays a central role for inducing apoptosis, and in experimental models of RD, dying phot...
متن کاملThe mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy.
The Hippo signaling pathway has recently moved to center stage in cardiac research because of its key role in cardiomyocyte proliferation and regeneration of the embryonic and newborn heart. However, its role in the adult heart is incompletely understood. We investigate here the role of mammalian Ste20-like kinase 2 (Mst2), one of the central regulators of this pathway. Mst2(-/-) mice showed no...
متن کاملRegulation of mammalian STE20-like kinase 2 (MST2) by protein phosphorylation/dephosphorylation and proteolysis.
Mammalian STE20-like kinase 2 (MST2), a member of the STE20-like kinase family, has been shown in previous studies to undergo proteolytic activation by caspase-3 during cell apoptosis. A few studies have also implicated protein phosphorylation reactions in MST2 regulation. In this study, we examined the mechanism of MST2 regulation with an emphasis on the relationship between caspase-3 cleavage...
متن کاملTumor Necrosis Factor- Mediates Photoreceptor Death in a Rodent Model of Retinal Detachment
METHODS. RD was induced by subretinal injection of hyaluronic acid. Photoreceptor degeneration was assessed by counting the number of apoptotic cells with TdT-dUTP terminal nickend labeling (TUNEL) 3 days after RD and measurement of the outer nuclear layer (ONL) thickness 7 days after RD. As the target of anti-inflammatory treatment, the expression of TNF , with or without dexamethasone (DEX) w...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2014
ISSN: 2041-4889
DOI: 10.1038/cddis.2014.218